Some predicted that boosters could reduce serious infections among immunocompromised people or others at high risk for complications. But to make a real dent in reducing transmission — the key to ending the pandemic — those who haven’t gotten vaccinated at all will have to get their first doses, Singer said. “The boosters probably have a limited impact on reducing the worst impacts, because it’s really unvaccinated people who are making up the supermajority of hospitalizations, ICU admissions and deaths,” Singer said. “If you have less infection, including breakthrough infections, you might break that train of transmission, but if you’re looking now, most of the transmission is occurring among people who have had zero vaccines.”
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