Dr. Peter Hotez, dean of the National School of Tropical Medicine at Baylor College of Medicine and co-director of the Texas Children’s Hospital Center for Vaccine Development

 Dr. Peter Hotez, dean of the National School of Tropical Medicine at Baylor College of Medicine and co-director of the Texas Children’s Hospital Center for Vaccine Development, said, “All we’re getting is snippets of data on the Israel Ministry of Health website.” He said he was curious whether, in addition to a decline in efficacy against mild infections, there was a significant drop in protection against hospitalizations for vaccinated people over time. John Grabenstein, a former executive director of medical affairs for vaccines at Merck, as well as a former immunologist for the Defense Department, agreed that more data need to be presented.

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The Israeli data is a snapshot, and I don't want to make a quick decision based on one snapshot

 "The Israeli data is a snapshot, and I don't want to make a quick decision based on one snapshot,” Grabenstein said. "I want to see multiple pictures, multiple views of the same thing, with the numbers beginning to coalesce around the same conclusion.” A recent study from the Mayo Clinic, however, also suggested waning immunity from the vaccines. The research, which hasn’t yet been published in a peer-reviewed journal, found that protection against infection during the height of the delta variant’s spread fell to 76 percent among those who had received the Moderna shots and 42 percent among those who got the Pfizer shots.

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There seems to be a dip in terms of immune responses

 “There seems to be a dip in terms of immune responses,” said an author of the paper, Dr. Abinash Virk, an infectious disease specialist at the Mayo Clinic. Her team is trying to determine whether the dip is truly due to waning immunity or whether the delta variant is mostly to blame. “It’s really difficult to sort this all out, because this is all happening concurrently,” Virk said, adding that mask mandates also went away as the delta variant began spreading. Some doctors questioned why the U.S. guidance appeared to be a blanket recommendation for everyone.

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What’s surprising about it is that it may be a universal recommendation that is based on time rather than on risk factor

 “What’s surprising about it is that it may be a universal recommendation that is based on time rather than on risk factor, and that would seem to be me to be a bit unusual, especially when we look at the rest of the planet, who have, in some areas, very low access to vaccines,” said Dr. Buddy Creech, director of the Vanderbilt Vaccine Research Program at the Vanderbilt University Medical Center. It’s also not clear what effect booster shots could have on the trajectory of the pandemic.

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Some predicted that boosters could reduce serious infections among immunocompromised people or others at high risk for complications

 Some predicted that boosters could reduce serious infections among immunocompromised people or others at high risk for complications. But to make a real dent in reducing transmission — the key to ending the pandemic — those who haven’t gotten vaccinated at all will have to get their first doses, Singer said. “The boosters probably have a limited impact on reducing the worst impacts, because it’s really unvaccinated people who are making up the supermajority of hospitalizations, ICU admissions and deaths,” Singer said. “If you have less infection, including breakthrough infections, you might break that train of transmission, but if you’re looking now, most of the transmission is occurring among people who have had zero vaccines.”

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After struggling for months to persuade Americans to get the COVID-19 vaccine

 After struggling for months to persuade Americans to get the COVID-19 vaccine, U.S. health officials could soon face a fresh challenge: talking vaccinated people into getting booster shots to gain longer-lasting protection as the delta variant sends infections soaring again. As early as Wednesday, U.S. health authorities are expected to recommend an extra dose of the vaccine for all Americans eight months after they get their second shot, according to two people who spoke to The Associated Press on condition of anonymity to discuss internal deliberations. That means the biggest vaccination drive in U.S. history is about to get even more extensive.

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Monday’s opener at Kauffman Stadium will be the first time Houston has made the trek to Kansas City this season to face the Royals

 Monday’s opener at Kauffman Stadium will be the first time Houston has made the trek to Kansas City this season to face the Royals. It should be a lay-up road trip on paper against what has looked like the third-worst team in the American League. Jake Odorizzi, Houston’s starting pitcher, has seen the Royals several times on the mound during his time with the Minnesota Twins. Not only has he faced them, but he actually pitched for them when his big-league career was starting to take flight in 2012.

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